PRP biofiller made from your own blood

Plasma gel, also called biofiller, is made entirely from your own blood. How it is produced, why it feels natural, and what studies show so far.

A filler without foreign material

Most fillers are manufactured products, usually cross-linked hyaluronic acid. A PRP biofiller, also called plasma gel or PRP gel, takes a fundamentally different approach: it is made entirely from the patient’s own blood. No synthetic material and no animal-derived substance is introduced. This autologous origin is what makes the concept so interesting for people who want to support their skin with the body’s own resources.

How plasma gel is made

The process starts like any PRP treatment: a small amount of blood is drawn and centrifuged, separating it into red blood cells, a platelet-rich layer and platelet-poor plasma. The platelet-poor plasma is then heated in a controlled way. Heat changes the structure of plasma proteins, mainly albumin, so the liquid turns into a soft, injectable gel. After cooling, the gel is often mixed with fresh liquid PRP, because heating denatures proteins, while the liquid PRP retains active platelets and their growth factors.

Origin100% ownMade only from your own blood

PreparationSame dayBlood draw, centrifugation, heating

CharacterSoft gelVolume plus regenerative signals

Why the approach is attractive

Autologous origin. Because the material comes from your own body, allergic or immune reactions to the material itself are not expected. Possible side effects mainly relate to the injection: swelling, redness, small bruises.

Natural feel. The gel is soft and is gradually broken down by the body’s own enzymes. Users and practitioners describe the result as subtle and natural, more a softening of hollows than a sharp contour.

Regenerative principle. When combined with liquid PRP, plasma gel provides volume together with the platelet growth factors known from PRP, such as PDGF, TGF-β and VEGF. These signals are associated with fibroblast activity and collagen production. The idea is a treatment that fills slightly and at the same time supports the skin’s own repair processes.

What studies show so far

The scientific literature on plasma gel is young but growing. In a study by Doghaim and colleagues (Journal of Cosmetic Dermatology, 2019), 52 women with facial wrinkles or tear trough hollowing received two sessions of plasma gel two weeks apart. Both groups showed significant clinical improvement that was maintained until the end of the three-month follow-up, and side effects were mild and transient. A 2025 pilot study with 30 patients (CosmoDerma) also reported good tolerability.

It is fair to say what these data cannot yet show. The studies are small, mostly without control groups, and follow patients for months rather than years. Preparation protocols, such as temperature and heating time, are not standardized. Compared with hyaluronic acid, plasma gel is expected to be broken down faster, so effects are likely to be shorter-lived; on the other hand, it leaves no foreign material behind.

Biofiller and hyaluronic acid compared

	PRP biofiller	Hyaluronic acid filler
Material	Your own plasma proteins and platelets	Manufactured, cross-linked gel
Allergy to the material	Not expected	Rare
Additional effect	Growth factors from PRP	Mainly volume
Breakdown	Gradual, by the body’s own enzymes	Can persist in tissue for a long time
Evidence	Early, small studies	Extensive, decades of data

Why it fits a regenerative philosophy

The current direction in aesthetic medicine is toward treatments that work with the body’s own biology rather than introducing permanent materials. This is also why HALO does not offer synthetic fillers (see Neuromodulators vs. fillers). Plasma gel belongs to the same family of ideas as PRP: using what the body already provides.

At HALO, autologous regeneration is available today as PRP for the full face and PRP for the eyes, which use liquid PRP to support skin quality and collagen. Whether a PRP-based treatment suits your skin, and what it can realistically achieve, is decided in a physician consultation.

References

Miron RJ, Pikos MA, Estrin NE, et al. Extended platelet-rich fibrin. Periodontol 2000. 2024;94(1):114-130. PMID 37986559.
Gheno E, Mourão CFAB, Mello-Machado RC, et al. In vivo evaluation of the biocompatibility and biodegradation of a new denatured plasma membrane combined with liquid PRF (Alb-PRF). Platelets. 2021;32(4):542-554. PMID 32531175.
Wu WS, Chen LR, Chen KH. Platelet-Rich Plasma (PRP): Molecular Mechanisms, Actions and Clinical Applications in Human Body. Int J Mol Sci. 2025;26(21). PMID 41226837.
Cho EB, Park GS, Park SS, et al. Effect of platelet-rich plasma on proliferation and migration in human dermal fibroblasts. J Cosmet Dermatol. 2019;18(4):1105-1112. PMID 30280483.
Doghaim NN, El-Tatawy RA, Neinaa YME. Assessment of the efficacy and safety of platelet poor plasma gel as autologous dermal filler for facial rejuvenation. J Cosmet Dermatol. 2019;18(5):1271-1279. PMID 30809897.
Davies C, Miron RJ. Autolougous platelet concentrates in esthetic medicine. Periodontol 2000. 2025;97(1):363-419. PMID 39086171.
Cruciani M, Masiello F, Pati I, et al. Platelet rich plasma for facial rejuvenation: an overview of systematic reviews. Blood Transfus. 2024;22(5):429-439. PMID 38557322.
Master M, Azizeddin A, Master V. Hyaluronic Acid Filler Longevity in the Mid-face: A Review of 33 Magnetic Resonance Imaging Studies. Plast Reconstr Surg Glob Open. 2024;12(7):e5934. PMID 39015357.